• Christina Weaver
Assistant Professor of Mathematics
Mathematics & Computer Science

Biography

Assistant Professor    Franklin & Marshall College, Lancaster, PA    2009-present
                     Department of Mathematics and Computer Science

Instructor    Mount Sinai School of Medicine, New York, NY.      2007-2009
                     Dept. of Neuroscience; Computational Neurobiology and Imaging Center.

Postdoc. Fellow    Mount Sinai School of Medicine, New York, NY.      2003-2007
                     Dept. of Biomathematical Sciences; Computational Neurobiology and Imaging Center.  

Education

Ph.D.   Stony Brook University, Stony Brook, NY             2003

            Applied Mathematics & Statistics


B.S.     Mount St. Mary's University, Emmitsburg, MD     1998

            Mathematics

Research

Computational neuroscience; image analysis; mathematical biology

Publications

  1. Steele JW, Brautigam H, Short J, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer’s disease mouse model. Journal of Comparative Neurology, in press.

  2. Luebke JI, Medalla M, Amatrudo JA, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A.  Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cerebral Cortex, in press.  PMID:  24323499

  3. Dickstein DL, Weaver CM, Luebke JI, Hof PR.  Dendritic spine changes associated with normal aging.  Neuroscience 251: 21-32, (2013).  PMID:  23069756.
  4. Amatrudo J, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices.  (Amatrudo & Weaver are joint first authors.) Journal of Neuroscience 32:  13644-60, (2012). PMID:  23035077.
  5. Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, Luebke JI, Hof PR, Weaver CM. Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. Journal of Comparative Neurology 520:  2888-902, (2012). PMID:  22315181. 
  6. Luebke JI, Weaver CM, Rocher AB, Rodriguez A, Crimins JL, Dickstein DL, Wearne SL, Hof PR.  Dendritic vulnerability in neurodegenerative disease:  insights from analyses of cortical pyramidal neurons in transgenic mouse models.  Brain Struct Func. 214(2-3): 181-199, (2010).  PMID:  20177698
  7. Weaver CM and Wearne SL.  Neuronal firing sensitivity to morphologic and active membrane parameters.  PLoS Computational Biology 4(1): e11, doi:10.1371/journal.pcbi.0040011 (2008).
  8. Weaver CM and Wearne SL.  The role of action potential shape and parameter constraints in optimization of compartment models.  Neurocomputing 69:  1053-1057, (2006).
  9. Weaver CM, Hof PR, Wearne SL, Lindquist WB.  Automated algorithms for multiscale morphometry of neuronal dendrites.  Neural Comput. 16: 1353-83, (2004).
  10. Weaver CM, Pinezich JD, Lindquist WB, Vazquez ME.  An algorithm for neurite outgrowth reconstruction.  J. Neurosci. Methods. 124: 197-205, (2003).
     

Student Collaborations

Matthew Nadherny ('13).  Summer 2012:  Improving detection of spatial clusters of dendritic spines.  Funded by NIA.

Daniel Hass (’13).  Spring 2010: Designing fitness functions for the optimization of neuron model parameters.  Summer 2010: The Applications of Neural Modeling in Researching Alzheimer’s Disease.  Funded by HHMI Program in Bioinformatics.

Gregory Schwartz (’11). Summer 2010: The optimization and application of brain metabolite concentration algorithms for clinical use.  Funded by HHMI Program in Bioinformatics.
 

Course Information

Spring 2014

  • MAT316, Probability & Statistics II
  • MAT110, Calculus II (two sections)

Past Semesters

  • MAT109, Calculus I, Fall 2009
  • MAT110, Calculus II, every semester
  • MAT216, Probability & Statistics I, Spring 2010; Spring 2011
  • MAT316:  Spring 2011, Spring 2012
  • MAT/CPS338: Computational Mathematics, Fall 2011, Fall 2013