Associate Professor Franklin & Marshall College, Lancaster, PA 2015-present
Department of Mathematics and Computer Science
Assistant Professor Franklin & Marshall College, Lancaster, PA 2009-2015
Department of Mathematics and Computer Science
Instructor Mount Sinai School of Medicine, New York, NY. 2007-2009
Dept. of Neuroscience; Computational Neurobiology and Imaging Center.
Postdoc. Fellow Mount Sinai School of Medicine, New York, NY. 2003-2007
Dept. of Biomathematical Sciences; Computational Neurobiology and Imaging Center.
Ph.D. Stony Brook University, Stony Brook, NY 2003
Applied Mathematics & Statistics
B.S. Mount St. Mary's University, Emmitsburg, MD 1998
I am passionate about mathematical modeling in general, but my research interests focus on computational neuroscience and image analysis. Specifically, I use compartmental modeling to study cellular mechanisms underlying working memory, and how those mechanisms are affected by aging and neurodegenerative disease. The models are constrained by morphologic and electrophysiological data collected by my colleagues at Boston University School of Medicine and the Icahn School of Medicine at Mount Sinai (New York, NY), resulting in multidisciplinary studies that demonstrate a unique approach to research. This requires methods for automated parameter optimization, a research area that we actively pursue. An intriguing outcome of our research is the application of sensitivity analysis approaches, to predict which electrical parameters to change, and by how much, will to compensate for a given age-, disease-, or development-related morphologic change, to restore normal function. We are extending these methods in new directions, and applying them to our current modeling problems to help us elucidate the mechanisms that shape neuronal function.
My research is funded by the National Institutes of Health (co-PI on an R01) and the National Science Foundation. I am a member of the Program Committee for the Organization for Computational Neurosciences.
- Coskren PJ, Luebke JI, Kabaso D, Wearne SL, Hof PR, Weaver CM. Functional consequences of age-related morphologic changes in pyramidal cells in the prefrontal cortex of the rhesus monkey. Journal of Computational Neuroscience 38(2): 263-83, (2015). PMID: 25527184.
Luebke JI, Medalla M, Amatrudo JA, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cerebral Cortex 25(6): 1454-68, (2015). PMID: 24323499.
Steele JW, Brautigam H, Short J, Sowa A, Shi M, Yadav A, Weaver CM, Westaway D, Fraser PE, St George-Hyslop PH, Gandy S, Hof PR, Dickstein DL. Early fear memory defects are associated with altered synaptic plasticity and molecular architecture in the TgCRND8 Alzheimer’s disease mouse model. Journal of Comparative Neurology 522: 2319-35, (2014). PMID: 24415002.
Dickstein DL, Weaver CM, Luebke JI, Hof PR. Dendritic spine changes associated with normal aging. Neuroscience 251: 21-32, (2013). PMID: 23069756.
- Amatrudo J, Weaver CM, Crimins JL, Hof PR, Rosene DL, Luebke JI. Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. (Amatrudo & Weaver are joint first authors.) Journal of Neuroscience 32: 13644-60, (2012). PMID: 23035077.
- Yadav A, Gao YZ, Rodriguez A, Dickstein DL, Wearne SL, Luebke JI, Hof PR, Weaver CM. Morphologic evidence for spatially clustered spines in apical dendrites of monkey neocortical pyramidal cells. Journal of Comparative Neurology 520: 2888-902, (2012). PMID: 22315181.
- Luebke JI, Weaver CM, Rocher AB, Rodriguez A, Crimins JL, Dickstein DL, Wearne SL, Hof PR. Dendritic vulnerability in neurodegenerative disease: insights from analyses of cortical pyramidal neurons in transgenic mouse models. Brain Struct Func. 214(2-3): 181-199, (2010). PMID: 20177698
- Weaver CM and Wearne SL. Neuronal firing sensitivity to morphologic and active membrane parameters. PLoS Computational Biology 4(1): e11, doi:10.1371/journal.pcbi.0040011 (2008).
- Weaver CM and Wearne SL. The role of action potential shape and parameter constraints in optimization of compartment models. Neurocomputing 69: 1053-1057, (2006).
- Weaver CM, Hof PR, Wearne SL, Lindquist WB. Automated algorithms for multiscale morphometry of neuronal dendrites. Neural Comput. 16: 1353-83, (2004).
- Weaver CM, Pinezich JD, Lindquist WB, Vazquez ME. An algorithm for neurite outgrowth reconstruction. J. Neurosci. Methods. 124: 197-205, (2003).
Matthew Nadherny ('13). Summer 2012: Improving detection of spatial clusters of dendritic spines. Funded by NIA.
Daniel Hass (’13). Spring 2010: Designing fitness functions for the optimization of neuron model parameters. Summer 2010: The Applications of Neural Modeling in Researching Alzheimer’s Disease. Funded by HHMI Program in Bioinformatics.
Gregory Schwartz (’11). Summer 2010: The optimization and application of brain metabolite concentration algorithms for clinical use. Funded by HHMI Program in Bioinformatics.
Dr. Timothy Rumbell (2013-15), now at IBM Watson Research Center.
Dr. Anniruddha Yadav (2009-2012), founder and CEO of Gauge Data Solutions.
- MAT110, Calculus II (two sections)
- MAT471, Nonlinear Dynamics
- MAT109, Calculus I, Fall 2009
- MAT110, Calculus II, seven semesters since 2009
- MAT216, Probability & Statistics I, Spring 2010, 2011, and 2015
- MAT316, Probability & Statistics II: Spring 2011, 2012, 2014
- MAT/CPS338: Computational Mathematics, Fall 2011, 2013, 2015
- MAT339: Mathematical Models, Fall 2014, 2015