Franklin & Marshall College Franklin & Marshall College

  • People
  • Clara S. Moore

    Associate Professor of Biology
    717-291-3887
    Office: LSP332D
    Summary: Developmental Biology. Molecular genetics of development; effects of trisomy on heart development and defects in mice.

    Education

    B.A. Loyola College
    Ph.D. Johns Hopkins University School of Medicine

    Research Interests

    Mouse models for Down syndrome, effects of trisomy on cardiovascular, skeletal, and other systems during development.

    Grants & Awards

    2011 Benedict-Miller Foundation, Research Grant.

    Publications

    Lorandeau C.G., L.A. Hakkinen and C.S. Moore (2011) Cardiovascular development and survival during gestation in the Ts65Dn mouse model for Down syndrome. Anatomical Record 294:93-101. Free PMC Article

    Moore C.S., C. Hawkins, A. Franca, A. Lawler, B. Devenney, I. Das and R.H. Reeves. (2010) Increased male reproductive success in Ts65Dn "Down syndrome" mice. Mammalian Genome 21:543-549. Free PMC Article

    Williams, A.D., C.H. Mjaatvedt, and C.S. Moore (2008) Characterization of the cardiac phenotype in neonatal Ts65Dn mice. Developmental Dynamics, 237:426-435. DOI: 10.1002/dvdy.21416

    Moore, C.S. and R.J. Roper (2007) The power of comparative and developmental studies for mouse models of Down syndrome. Mammalian Genome, 18:431-443. Link to pdf

    Moore C.S. (2006) Postnatal lethality and cardiac anomalies in the Ts65Dn Down syndrome mouse model. Mammalian Genome, 17:1005-1012 with cover illustration. Link to pdf

    Presentations

    2009  Moore C.S.  Teaching research skills through collaborative research projects in developmental biology. Society for Developmental Biology Annual Meeting, San Francisco, CA.

    2008    Moore C.S., M. Demczko, N. Gotlieb and L. Hakkinen. Development of cardiovascular defects in the murine Ts65Dn Down syndrome model. Mammalian Genome Conference. Prague, Czech Republic

    2008  Demczko M., N. Gotlieb, L. Hakkinen and C.S. Moore. Characterization of cardiovascular development in the murine Ts65Dn Down syndrome model.  AnEUploidy Workshop, Geneva, Switzerland. Selected platform presentation.

    Student Collaborations

    Student Presentations at Research Conferences:

    Franca, A. Kelly E.M. and C.S. Moore. Proteomic identification of protein misexpression during cardiogenesis in the Ts65Dn Down syndrome mouse model. 2011 Mouse Genetics Conference, Washington, D.C.

    Tischbein M and C.S. Moore. Evaluation of skeletogenesis in the Ts65Dn mouse model for Down syndrome at embryonic day 13.5-14.5. 2011 Mouse Genetics Conference, Washington, D.C.

    Kelly E.M, M.M. Demczko and C.S. Moore. The effect of gene dosage imbalance and NFATc1 localization on endocardial cushion development in the Ts65Dn mouse model for Down syndrome. 2009 Society for Developmental Biology Annual Meeting, San Francisco, CA.

    Gotlieb N.R., L.A. Hakkinen and C.S. Moore.  Quantification and analysis of apoptosis in embryonic atrioventricular endocardial cushions of the Ts65Dn mouse model for Down syndrome. 2009 Weinstein Cardiovascular Development Conference, San Francisco, CA.

    Lorandeau C.G. and C.S. Moore.  Analysis of cardiovascular development and transmission rate during development in the Ts65Dn mouse model for Down syndrome. 2009 Weinstein Cardiovascular Development Conference, San Francisco, CA.

    Hakkinen, L. A. and C.S. Moore. Embryonic cardiovascular analysis in the Ts65Dn mouse model for Down syndrome. 2007 Pan American Congress in Developmental Biology, Cancun, Mexico. Honorable mention, Student Best Poster Contest.

    Williams, A.D. and C.S. Moore. Analysis of cardiovascular anomalies in the Ts65Dn mouse model for Down syndrome. 2007 Society for Developmental Biology Mid-Atlantic Conference, Princeton, NJ.

    Rush, L.M., C.M. Mulcahy and C.S. Moore. Structural and protein analysis of mouse Ts65Dn embryonic stem cells differentiating into cardiomyocytes. 2004 Society for Developmental Biology, Northwest Regional Conference, Friday Harbor, WA.

    Course Information