Franklin & Marshall College Franklin & Marshall College

Tony Wynshaw-Boris '77 to Discuss "Development of the Nervous System" April 17

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Tony Wynshaw-Boris '77, professor of pediatrics/medicine in the cancer biology program at the University of California-San Diego, will discuss "Development of the Nervous System" on Thursday, April 17 at 7:30 p.m. in the Bonchek Lecture Hall, Barshinger Life Sciences and Philosophy Building.

The talk is part of the Faculty Symposium Speaker Series in celebration of the opening of the Barshinger Life Sciences and Philosophy Building, and is sponsored by the Center for Liberal Arts and Society and the Biology Department. It is free and open to the public.

Wynshaw-Boris' laboratory is focused on understanding genetic and biochemical pathways important for the development and function of the mammalian central nervous system.

Over the past decade, powerful strategies for the mapping and positional cloning of a number of genes associated with human genetic diseases have been developed, and techniques for manipulating the mammalian genome via transgenic technology have been refined. Wynshaw-Boris and his associates have taken advantage of these advances to create and characterize mouse models of human and mammalian genetic diseases that affect the central nervous system.

As sources of genes that affect the central nervous system, theyuse positionally cloned genes for human diseases that have central nervous system disorders, or genes from conserved evolutionary pathways that are predicted to impact on central nervous system development and/or function. Mouse genes are cloned, and used to create mouse models. The phenotype of these models are carefully assessed.

The primary goal is to use these models as entry points to investigate pathways critical for normal brain development and function. They anticipate that this avenue of investigation will lead to a greater understanding of these diseases, uncover novel therapeutic approaches, and provide models to test therapies.

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