• Chemistry Class
Associate Professor of Chemistry
Chemistry

Office: HAC 406
Lab: ​HAC 404

Spring  2015 Office Hours:

Biography

Link to Fenlon CV

Education

B.S. St. Lawrence University, 1990
Ph.D. University of Illinois, 1995

Research

We use organic synthesis to build molecules for practical purposes. Research projects involve: 

  1. The synthesis of nucleotides and proteins with an azide (R-N3) probe to monitor electrostatic environments and solvent dynamics by vibrational (IR) spectroscopy.
  2. The design and synthesis of air-stable, water-soluble organic radicals such as sulfonated BDTPP for dynamic nuclear polarization imaging. 
  3. Molecular knots.  
  4. The design and synthesis of musks as perfumes.
  5. Collaborative work to synthesize ganglioside GM3 to help Amish children.
  6. The history of organic chemistry.

Research Collaborations:

     Nucleic Acid Probes
     
Dr. Scott Brewer
     Dr. Matthew Tucker
     Dr. Christopher Cheatum
     Dr. Steven Corcelli 
     Dr. Alex MacKerell

     History of Organic Chemistry
     Dr. Brian Myers

Link to more Research Information

 

Grants & Awards

NIH AREA grant - "Investigating Protein Hydration and Structure with Azide Probes." 2014 to 2017. $272,300.

NIH grant - "Development and Application of Multi-Spectroscopic, Site-Specific (MS3) Probes of Nucleic Acid Structure."  June 2010 through May 2013.  $195,895.
 

Publications

1999 - Present
(Undergraduate student coauthor are in bold.)

Tookmanian, E. M.; Fenlon, E. E.; Brewer, S. H. Synthesis and protein incorporation of azido-modified unnatural amino acids. RSC Advances 2015, 5, 1274-1281.

Fenlon, E. E.; Myers, B. J. Profiles in Chemistry: A Historical Perspective on the National Organic Symposium,  Journal of Organic Chemistry 2013, 78, 5817-5831.

Lipkin, J.S.; Song, R.; Fenlon, E.E.; Brewer, S.H. Modulating Accidental Fermi Resonance: What a Difference a Neutron Makes. Journal of Physical Chemistry Letters 201121672-1676.

Gai, X.S.; Coutifaris, B.A.; Brewer, S.H.; Fenlon, E.E. A Direct Comparison of Azide and Nitrile Vibrational Probes. Physical Chemistry Chemical Physics 2011, 13, 5926-5930.

Tucker, M.J.; Gai, X.S.; Fenlon, E.E.; Brewer, S.H.; Hochstrasser, R.M. 2D IR Photon Echo of Azido-Probes for Biomolecular Dynamics.Physical Chemistry Chemical Physics 201113, 2237-2241.

Gillies, A.T.; Gai, X.S.; Buckwalter, B.L.; Fenlon, E.E.; Brewer, S.H. 15N NMR Studies of a Nitrile-Modified Nucleoside. Journal of Physical Chemistry B 2010114, 17136-17141.


Fenlon, E.E. Tying Up Some Loose Ends. Nat. Chem. 2010, 2, 156-157.

Gai, X.S.; Brewer, S.H.; Fenlon, E.E. A Sensitive Multispectroscopic Probe for Nucleic Acids. J. Phys. Chem. B 2010, 113, 7958-7966.

Watson, M. D.; Gai, X. S.; Gillies, A. T.; Brewer, S. H.; Fenlon, E. E. A Vibrational Probe for Local Nucleic Acid Environments: 5-Cyano-2-deoxyuridine. J. Phys. Chem. B 2008, 112, 13188-13192.

Fenlon, E. E. Open Problems in Chemical Topology. Eur. J. Org. Chem. 2008, 5023-5035.

Fenlon, E. E.; Ito, B. R. The Thread & Cut Method: Syntheses of Molecular Knot Precursors. Eur. J. Org. Chem. 2008, 3065-3068.

Silverman, L. N.; Pitzer, M. E.; Ankomah, P. O.; Boxer, S. C.; Fenlon, E. E.. Vibrational Stark Effect Probes for Nucleic Acids. J. Phys. Chem. B 2007 111, 11611-11613.

Rink, C. M.; Mauck, M. C.; Asif, I.; Pitzer, M. E.; Fenlon, E. E.. Syntheses of Silatranyl- and Germatranyl-uridines, Org. Lett. 2005, 7, 1165-1168.

Black, C. A.; Ucci, J. W.; Vorpagel, J. S.;   Mauck, M. C.; Fenlon, E. E. Stereoselective and improved syntheses and anticancer testing of 3'-O-silatranylthymidines. Bioorg. Med. Chem. Lett. 2002, 12, 3521-3523.

Sculimbrene, B. R.; Decanio, R. E.; Peterson, B. W.; Muntel, E. E.; Fenlon, E. E. Silatranyl-nucleosides: transition state analogues for phosphoryl transfer reactions. Tetrahedron Lett. 2001, 42, 4979–4982.

Kolotuchin, S. V.; Thiessen, P.A.; Fenlon, E. E.; Wilson, S. R.; Loweth, C. J.; Zimmerman, S. C. Self-Assembly of 1,3,5-Benzenetricarboxylic (Trimesic) Acid and Its Analogs. Chemistry–A European Journal 1999, 5, 2537-2547.




Course Information

Dr. Edward Fenlon teaches the following courses:

Chem 112 - General Chemistry II
Chem 211/212 - Organic Chemistry I and II
Chem 323 - Medicinal Chemistry

FND 182 - Pills, Pills, Pills
​CNX 230 - Mars & Venus on the Pill


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