Franklin & Marshall College Franklin & Marshall College

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  • Kenneth R. Hess

    Professor of Chemistry
    Office: HAC317A


    B.A. Gettysburg College, 1982
    Ph.D. University of Virginia, 1986

    Research Interests

    Our research involves the application of liquid chromatography–mass spectrometry (LC-MS) methods to analytical problems of importance.  The Chemistry Department houses an Agilent 1100 HPLC–SL Ion Trap system that allows chromatographic separation and mass spectral identification of analytes, including Mass Spectrometry/Mass Spectrometry (MS/MS) methods. In previous work the instrument was employed to verify the site-specific incorporation of unnatural amino acids in proteins. Currently, we are working with the Clinic for Special Children in Strasburg, PA to address clinical aspects of GM3 synthase deficiency, a rare autosomal recessive epilepsy syndrome ob-served in the Amish population. A key component of the project is the development and implementation of analytical methodologies for the analysis of ganglioside molecules using LC-MS and fluorescence techniques. 



    Student coauthor bold.

    Peeler, J.C.; Woodman, B.F.; Averick, S.; Miyake-Stoner, S.J.; Stokes, A.L.; Hess, K.R.; Matyjaszewski, K.; Mehl, R.A. Genetically Encoded Initiator for Polymer Growth from Proteins. J. Am. Chem. Soc. 2010, 132, 13575..

    Miyake-Stoner, S.J.; Miller, A.M.; Hammill, J.T.; Peeler, J.C.; Hess, K.R.; Mehl, R.A.; Brewer, S.H. "Probing Protein Unfolding Using Site-Specifically Encoded Unnatural Amino Acids as FRET Donors with Tryptophan." Biochemistry 2009, 48, 5953-5962.

    Jackson, J.C., Duffy, S.P., Hess, K.R., Mehl, R.A. "Improving Nature's Active Site with Genetically Encoded Unnatural Amino Acids." J. Am. Chem. Soc. 2006, 128, 11124-11127.

    D.C. Powers, A.T. Higgs, M.L. Obley, P.A. Leber, K.R. Hess, C.H. Yoder. "An Environmental Project for First Year Chemistry Students: Analysis of Natural Buffer Systems and the Impact of Acid Rain." J. Chem. Educ. 2005, 826, 274-2770.

    A.L. Schilling, K.R. Hess, P.A. Leber, C.H. Yoder. "A Simulation of the Interaction of Acid Rain with Soil Materials," J. Chem. Educ. 2004, 81, 246-247.

    H.D. Harle, J.A. Ingram, P.A. Leber, K.R. Hess, C.H.Yoder. "A Simple Method for Determination of Solubility in the First-Year Laboratory", J. Chem. Educ. 2003, 80, 560.

    H.D. Harle, P.A. Leber, K.R. Hess, C.H.Yoder. "A Concept-Based Environmental Project for the First-Year Laboratory: Remediation of Barium-Contaminated Soil by In Situ Immobilization", J. Chem. Educ. 2003, 80, 561-562.

    Jared D. Bender, Arthur J. Catino, Kenneth R. Hess, Michael E. Lassman, Phyllis A. Leber, Carl S. Pike, Michael D. Reinard and Neil A. Strotman, "A Biochemical GC/MS Application for the Organic Chemistry Laboratory: Determination of FAME Composition in Arabidopsis thaliana", J. Chem. Ed. 2000, 77, 1466.

    C. Yoder, O. Retterer, M. Thomsen, and K. Hess, Interactive Chemistry: Models and Applications (an interactive, CD-ROM based text for introductory chemistry), Academy Artworks, York, PA, 1999.

    C.M. Barshick, K.R. Hess, A.L. Zook, R.E. Steiner, and F.L. King, "An Investigation into the Analytical Utility of Plasma etching in Reactive Glow Discharge Plasmas", Applied Spectroscopy 1999, 53, 65.

    D.A. Day, A.L. Zook, C.M. Barshick, and K.R. Hess, "Electrochemical Deposition of Metals in the Preparation of Standard Materials for Glow Discharge Mass Spectrometry", Microchemical Journal 1997, 55, 208.

    X. Xiong, J.M.R. Hutchinson, K.R. Hess, J.D. Fassett, and T.B. Lucatorto, "A Novel Approach to Resonance Ionization Mass Spectrometry Employing a Glow Discharge Atom Source", Spectrochimica Acta, Part B, 1996, 51B, 1463.

    C.H. Yoder, W.D. Smith, V.L. Katolik, K.R. Hess, M.W. Thomsen, C.S. Yoder, and E.R. Bullock, “The Synthesis and Analysis of Copper(II) Carboxylates,” J. Chem. Educ.1995, 72, 267.

    K.R. Hess, W.D. Smith, M.W. Thomsen, and C.H. Yoder, “An Introductory Infrared Spectroscopy Experiment”, J. Chem. Educ. 1995, 72, 655.

    X. Xiong, J.M.R. Hutchinson, J.D. Fassett, T.B. Lucatorto, F.J. Schima, W.A. Bowman, and K.R. Hess, "Study of Laser Resonance Ionization Spectroscopy Using a Glow Discharge Source", AIP Conference Proceedings 329: Resonance Ionization Spectroscopy 1994, American Institute for Physics Press, New York, p. 316-319, 1995.

    Course Information

    Dr. Kenneth Hess teaches the following courses:

    Chem 111/112 - General Chemistry I and II
    Chem 221 - Chemcal Analysis
    Chem 374 - Chemical Instrumentation