Franklin & Marshall College Franklin & Marshall College

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  • Pablo D. Jenik

    Assistant Professor of Biology
    717-358-4431
    Office: LSP354A
    Summary: Developmental Genetics; Development of the embryo in the plant Arabidopsis thaliana.

    Education

    Ph.D. in Molecular, Cellular and Developmental Biology, Yale University, 2000

    Licenciado (B.Sc./M.Sc.) in Biology, University of Buenos Aires, Argentina, 1994

    Research Interests

    I am interested in understanding how plant embryos are made. I am particularly interested in the processes of patterning (how different cell types are specified in the right places) and maturation (the accumulation of products necessary to germinate succesfully). The embryo of the mustard weed Arabidopsis thaliana is an excellent model system to address these issues, since its development is characterized by extremely regular cell divisions and patterning decisions, which make it easy to find mutants that affect these events.

    In my lab we are characterizing a collection of embryonic mutants that are altered in different aspects of embryogenesis. The work involves a careful characterization of the phenotypes, finding which is the gene that has been mutated, and then using genetic and molecular approaches to understand how the products of those genes regulate development. So far we have worked on genes that encode products involved in the synthesis of microRNAs (DICER-LIKE1) and regulated protein degradation (proteasome subunit RPN5a, subunits of the CSN complex). We have found that some of these genes are involved in patterning and maturation (DICER-LIKE1), while others in the regulation of the cell cycle (RPN5a, CSN complex). We have now started studying the function and regulation of a pair of genes (ASIL1 and 2) that have been proposed to regulate embryonic maturation.

    Grants & Awards

    P.D. Jenik and B.D. Gregory "Global analysis of RNA-dependent RNA Polymerase function" National Science Foundation ROA grant (2013)

    Publications

    As faculty (*undergraduate or ^high-school teacher co-authors):

    Barr, M.S.^, Willmann, M.R. and Jenik, P.D. (2012) “Is there a role for trihelix transcription factors in embryo maturation?” Plant Signaling & Behavior 7: 205-209. [PubMed]

    Willmann, M.R., Mehalick, A.J.*, Packer, R.L.* and Jenik, P.D. (2011) microRNAs regulate the timing of embryo maturation in Arabidopsis. Plant Physiology 155: 1871-1884. [PubMed]

    Book, A.J., Smalle, J., Lee, K-H., Yang, P., Walker, J.M., Casper, S., Holmes, J.H., Russo, L.A.*, Buzzinotti, Z.W.*, Jenik, P.D. and Vierstra, R.D. (2009) The RPN5 subunit of the 26S proteasome is essential for gametogenesis, sporophyte development, and complex assembly in Arabidopsis. Plant Cell 21: 460-478. [PubMed]

    Jenik, P.D., C.S. Gillmor and W. Lukowitz. (2007) Embryonic patterning in Arabidopsis. Annual Review of Cell and Developmental Biology 23: 207-236 (Review Article). [PubMed]

    As post-doc:
     

    Jenik, P.D., R.E.J. Jurkuta and M.K. Barton. (2005) Interactions between the cell cycle and embryonic patterning in Arabidopsis uncovered by a mutation in DNA polymerase epsilon. Plant Cell 17: 3362-3377 (“Recommended” by the Faculty of 1000 Biology). [PubMed]

    Jenik, P.D. and M.K. Barton (2005). Surge and destroy: the role of auxin in plant embryogenesis. Development 132: 3577-3585. (Review Article). [PubMed]

    As a Ph.D. student:

    Irish, V.F. and P.D. Jenik (2001) Cell lineage, cell signaling and the control of plant morphogenesis. Current Opinion in Genetics & Development 11: 424-430. (Review Article). [PubMed]

    Jenik, P.D. and V.F. Irish (2001). The Arabidopsis floral homeotic gene APETALA3 differentially regulates intercellular signaling required for petal and stamen development. Development 128: 13-23. [PubMed]

    Jenik, P.D. and V.F. Irish (2000). Regulation of cell proliferation patterns by homeotic genes during Arabidopsis floral development. Development 127:1267-1276. [PubMed]

    Irish, V., C. Day, K. Bouhidel, B. McGonigle, S. Carr, T. Hill, E. Wright and P. Jenik (1996). Genetic analysis of petal and stamen development in Arabidopsis. Flowering Newsletter 21: 3-9. (Review Article).

    As an undergraduate student:

    Rossi, C., O. Rey, P. Jenik and M.T. Franze-Fernandez (1996). Immunological identification of Tacaribe virus proteins. Research in Virology 147: 203-211. [PubMed]

    Course Information

    BIO 305 Genetics (Every Fall)

    FND 171 Modern Human Evolution (Fall 2010, Spring 2013)

    BIO 375 Genetics and regulation of gene expression (Spring 2011, 2012)

    BIO 372 Evolutionary Developmental Biology (Spring 2013)

    BIO 230 Cell Biology (Spring 2009, 2010)

    BIO 379 Genetics and Molecular Biology of Plants (Spring 2008)