Jing Hu Associate Professor of Computer Science
Education
Ph.D. in Computer Science, Utah State University (2009)
B.S. in Computer Science, Xidian University (1999)
Research
My research interests lie broadly in bioinformatics and computational biology. The primary research goal is to develop and apply computationally intensive techniques such as data mining and machine learning algorithms to address challenges in understanding biological systems, which involves theories and techniques from multi-disciplinary fields of computer science, statistics, biochemistry and biophysics. A general workflow of my research is to identify and study biological problems, construct computational models, develop and apply efficient and effective machine learning techniques to systematically analyze and understand biological processes. Specifically, my recent research focuses on problems such as prediction of protein functions and functional sites, identification of deleterious SNPs and indels, and drug repositioning.
Publications
(*indicates student co-author)
2023
30. Hu J. and Du Y.* (2023) redicting Moonlighting Proteins from Protein Sequence. In Proceedings
of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies
- Volume 3: BIOINFORMATICS, ISBN Not Available, ISSN 2184-4305, pages 270-275.
2019
29. Hu J. and Keri F* (2019) TLC_SDSB: A Two-Layer Structured Classifier for Identifying Single-Stranded
and Double-Stranded DNA-Binding Proteins from Protein Sequence. (Short Paper) In
proceedings of th15th International Symposium on Bioinformatics Research and Applications
(ISBRA), Barcelona, Spain, 3-6 June, 2019 (ISBRA'19).
2017
28. Hu J. and Andrews B* (2017) Distinguishing Long Non-coding RNAs From mRNAs Using a Two-layer
Structured Classifier. Accpted by 2017 IEEE 7th International Conference on Computational
Advances in Bio and Medical Sciences (ICCABS'17).
2015
27. Andrews B* and Hu J. (2015) A two-stage classifier for predicting protein-ATP binding sites from protein
sequence. In proceedings of 2015 IEEE Conference on Computational Intelligence in
Bioinformatics and Computational Biology (CIBCB'15), Niagara Falls, ON, Canada.
2014
26. Hu J and Yan X. (2014) Predicting Protein Submitochondrial Locations Using a K-Nearest
Neighbor Method Based On the Bit-Score Weighted Euclidean Distance. Accepted by The
10th International Symposium on Bioinformatics Research and Applications (ISBRA2014).
25. Hu J (2014) BLKnn: A Novel K-Nearest Neighbor Method For Predicting Bioluminescent Proteins.
Accepted by 2014 IEEE Conference on Computational Intelligence in Bioinformatics and
Computational Biology (CIBCB 2014)
2013
24. Hu J, Ng PC (2013) SIFT Indel: Predictions for the Functional Effects of Amino Acid Insertions/Deletions
in Proteins. PLoS ONE 8(10): e77940.doi:10.1371/journal.pone.0077940. (Impact factor: 3.730)
23. Hu, J., Forcier, A.* and Yan, C. A Method For Predicting ATP-Binding Pockets Based On Amino
Acid Microenvironment. Accepted by the 5th International Conference on Bioinformatics
and Computational Biology (BICoB).
2012
22. Yan, X., Gurtler, J.B., Fratamico, P.M., Hu, J., Juneja, V.K. Phylogenetic Analysis of Bacterial Toxin MazF Protein among Probiotic
Strains and Food-borne Pathogens and Potential Implications of Engineered Probiotics
Intervention in Food. Cell & Bioscience, 2012, 2:39. (impact factor: 3.00)
21. Sim, N.L., Kumar, P., Hu, J., Henikoff, S., Schneider, G., and Ng, P. SIFT web server: predicting effects of
amino acid substitutions on proteins. Nucleic Acid Research, 2012 Jul;40 (Web Server issue): W452-7 (impact factor: 8.278). (PMID: 22689647)
20. Hu, J., and Ng, P. Predicting the Effect of Frameshifting indels. Genome Biology, 2012, 13:R9 (impact factor: 10.3). (PMID:22322200)
19. Hu, J., and Yan, X. BS-KNN: An Effective Algorithm for Predicting Protein Subchloroplast
Localization. Evolutionary Bioinformatics 2012:8 79-87. (doi: 10.4137/EBO.S8681) (impact factor: 2.864)
2011
18. Yan, X., Gurtler, J., Fratamico, P., Hu, J., Gunther, N. W. IV., Juneja, V., and Huang, L. Comprehensive Approaches for Molecular
Biomarker Discovery for the Detection and Identification of Cronobacter spp. (Enterobacter
sakazakii), Salmonella and Other Foodborne Pathogens. Applied and Environmental Microbiology, Vol 77, No. 5, pp 1833-1843, March 2011. (PMID: 21239552) (Impactor factor: 3.778)
17. Hu, J., Schilder, M.* and Yan, X. A Neighor-Weighted K-Nearest Neighbor Method For Predicting
Protein Subnuclear Localizations (poster paper). IEEE 1st International Conference
on Computational Advances in Bio and Medical Sciences (ICCABS'11), pp. 247, Feb 3-. 2011, Orlando, FL, USA. (ISBN: 978-1-61284-851-8 ) (doi 10.1109/ICCABS.2011.5729900
) (Acceptance rate: 42%)
2010
16. Hu, J. and Yan, C. A comparative Analysis of Protein Interfaces. Protein Pept. Lett., vol 17, issue 11, 1450-1458, 2010. (Impact factor: 1.755)
15. Hu, J. Predicting Subcellular Localization of Gram-negative Proteins with Improved Performance.
In proceeding of 2nd International Conference on Bioinformatics and Computational
Biology (BICoB), Honolulu, Hawaii, USA, March 24-26, 2010. (Acceptance rate: 45%)
2009
14. Hu, J. and Yan, C. A tool for calculating binding-site residues on proteins from PDB structures. BMC Structural Biology, 2009, 9:52.3. (Impact factor: 2.79)
2008
13. Hu, J. and Yan, C. A Method for Discovering Transmembrane Beta-barrel Proteins in Gram-negative
Bacterial Proteomes.Computational Biology and Chemistry, 2008 32:298-301. (Impact factor: 1.37)
12. Hu, J. and Yan, C. Identification of Deleterious Non-synonymous Single Nucleotide Polymorphisms
Using Only Sequence-derived Information, BMC Bioinformatics, 2008, 9:297. (Impact factor: 3.43)
11. Hu, J. and Yan, C. Protein Subcellular Localisation Prediction with Improved Performance. International Journal of Functional Informatics and Personalised Medicine. 2008, 1 (3), 321-328.
10. Hu, J., and Yan, C. HMM_RA: An Improved Method for Alpha-helical Transmembrane Protein Topology
Prediction. Bioinformatics and Biology Insights, 2008 2: 67-74.
9. Yan, C., Hu, J., and Wang, Y. Discrimination of Outer Membrane Proteins Using a K-nearest Neighbor
Method. Amino Acids,2008 35(1):65-73. (Impact factor: 3.88)
8. Yan, C., Hu, J., and Wang, Y. Discrimination of Outer Membrane Proteins with Improved Performance. BMC Bioinformatics,2008, 9:47. (Impact factor: 3.43)
7. Hu, J. and Yan, C. Mining Sequence Features for DNA-binding Site Prediction. In Proceedings
of IEEE Symposium on Computational Intelligence in Bioinformatics and Computational
Biology, 2008.
2007
6. Hu, J. and Yan, C. Predicting Protein Subcellular Localizations Using Weighted Euclidian
Distance. In Proceedings of IEEE 7th International Symposium on BioInformatics and
BioEngineering, 2007, 1370-1373.
2006
5. Yan, C. and Hu, J. An Exploration to the Combining of Solvent Accessibility With Amino Acid Sequence
in the Identification of Helix-Turn-Helix motifs, WSEAS Transaction on Biology and
Biomedicine, 2006,6(3): 477-484.
4. Yan, C. and Hu, J. Identification of Helix-Turn-Helix Motifs From Amino Acid Sequence. In Proceedings
of IEEE Symposium on Computational Intelligence in Bioinformatics and Computational
Biology, 2006, 1-7.
3. Yan, C. and Hu, J. A Hidden Markov Model for the Identification of Helix-Turn-Helix Motifs. In Proceedings
of WSEAS International Conference on Cellular and Molecular Biology-Biophysics and
Bioengineering, 2006, 14-19.
2. de Garis, H., Liu, R., Huang, D. and Hu, J. Artificial Brains. An Inexpensive Method for Accelerating the Evolution of Neural
Network Modules for Building Artificial Brains, In Proceedings of the AGI Workshop,
2006, 144-158.
2005
1. Flann N. S., Hu J., Bansal M., Patel V. and Podgorski G. Biological Development of Cell Patterns: Characterizing
the Space of Cell Chemistry Genetic Regulatory Networks. In Proceedings of Eighth
European Conference on Artificial Life, 2005, 57-66.
Presentations
1. Poster presentation, "Predicting the effects of 3n indels", The Pacific Symposium
on Biocomputing (PSB) 2013.
2. Invited Talk: "Predicting the effects of frameshifting indels using a machine learning
approach", Dickinson College, 2012.
3. Poster presentation, "SIFT Indel: an on-line tool for predicting the effects of
frame shifting indels", 2012 Pacific Symposium on Biocomputing (PSB 2012)
4. Poster presentation, "BS-KNN: A K-Nearest Neighbor Method for Predicting Protein
Subchloroplast Locations Based on Bit-Score Weighted Euclidian Distance", ACM-BCB
2011
5. Oral Presentation: "Identification of Transmembrane β-Barrel Proteins Using a
K-Nearest Neighbor Method Based On Weighted Manhattan Distance", 2010 International
Conference on Bioinformatics & Computational Biology (BIOCOMP' 10), Las Vegas, NV,
July 12-15, 2010.
6. Oral Presentation: "Predicting Subcellular Localization of Gram-negative Proteins
with Improved Performance", 2nd International Conference on Bioinformatics and Computational
Biology (BICoB), Honolulu, Hawaii, USA, March 24-26, 2010.
7. Poster Presentation: "A Useful Tool for Calculating Binding-site Residues on
Proteins from PDB Structures", 7th Annual Rocky Mountain Bioinformatics Conference,
Aspen, CO, December 10-12, 2009.
Grants and Awards
Computational Drug Repositioning (Second Amendment), Industry grant offered by GlaxoSmithKline
LLC, $39,972, 7/1/2014 - 6/30/2015, Principal Investigator.
Computational Drug Repositioning (First Amendment), Industry grant offered by GlaxoSmithKline
LLC, $38,609, 8/1/2013 - 6/30/2014, Principal Investigator.
Computational Drug Repositioning, Industry grant offered by GlaxoSmithKline LLC, $99,723,
8/1/2012 - 7/31/2013, Principal Investigator.
Publications
(*indicates student co-author)
2023
30. Hu J. and Du Y.* (2023) redicting Moonlighting Proteins from Protein Sequence. In Proceedings of the 16th International Joint Conference on Biomedical Engineering Systems and Technologies - Volume 3: BIOINFORMATICS, ISBN Not Available, ISSN 2184-4305, pages 270-275.
2019
29. Hu J. and Keri F* (2019) TLC_SDSB: A Two-Layer Structured Classifier for Identifying Single-Stranded and Double-Stranded DNA-Binding Proteins from Protein Sequence. (Short Paper) In proceedings of th15th International Symposium on Bioinformatics Research and Applications (ISBRA), Barcelona, Spain, 3-6 June, 2019 (ISBRA'19).
2017
28. Hu J. and Andrews B* (2017) Distinguishing Long Non-coding RNAs From mRNAs Using a Two-layer Structured Classifier. Accpted by 2017 IEEE 7th International Conference on Computational Advances in Bio and Medical Sciences (ICCABS'17).
2015
27. Andrews B* and Hu J. (2015) A two-stage classifier for predicting protein-ATP binding sites from protein sequence. In proceedings of 2015 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB'15), Niagara Falls, ON, Canada.
2014
26. Hu J and Yan X. (2014) Predicting Protein Submitochondrial Locations Using a K-Nearest Neighbor Method Based On the Bit-Score Weighted Euclidean Distance. Accepted by The 10th International Symposium on Bioinformatics Research and Applications (ISBRA2014).
25. Hu J (2014) BLKnn: A Novel K-Nearest Neighbor Method For Predicting Bioluminescent Proteins. Accepted by 2014 IEEE Conference on Computational Intelligence in Bioinformatics and Computational Biology (CIBCB 2014)
2013
24. Hu J, Ng PC (2013) SIFT Indel: Predictions for the Functional Effects of Amino Acid Insertions/Deletions in Proteins. PLoS ONE 8(10): e77940.doi:10.1371/journal.pone.0077940. (Impact factor: 3.730)
23. Hu, J., Forcier, A.* and Yan, C. A Method For Predicting ATP-Binding Pockets Based On Amino Acid Microenvironment. Accepted by the 5th International Conference on Bioinformatics and Computational Biology (BICoB).
2012
22. Yan, X., Gurtler, J.B., Fratamico, P.M., Hu, J., Juneja, V.K. Phylogenetic Analysis of Bacterial Toxin MazF Protein among Probiotic Strains and Food-borne Pathogens and Potential Implications of Engineered Probiotics Intervention in Food. Cell & Bioscience, 2012, 2:39. (impact factor: 3.00)
21. Sim, N.L., Kumar, P., Hu, J., Henikoff, S., Schneider, G., and Ng, P. SIFT web server: predicting effects of amino acid substitutions on proteins. Nucleic Acid Research, 2012 Jul;40 (Web Server issue): W452-7 (impact factor: 8.278). (PMID: 22689647)
20. Hu, J., and Ng, P. Predicting the Effect of Frameshifting indels. Genome Biology, 2012, 13:R9 (impact factor: 10.3). (PMID:22322200)
19. Hu, J., and Yan, X. BS-KNN: An Effective Algorithm for Predicting Protein Subchloroplast Localization. Evolutionary Bioinformatics 2012:8 79-87. (doi: 10.4137/EBO.S8681) (impact factor: 2.864)
2011
18. Yan, X., Gurtler, J., Fratamico, P., Hu, J., Gunther, N. W. IV., Juneja, V., and Huang, L. Comprehensive Approaches for Molecular Biomarker Discovery for the Detection and Identification of Cronobacter spp. (Enterobacter sakazakii), Salmonella and Other Foodborne Pathogens. Applied and Environmental Microbiology, Vol 77, No. 5, pp 1833-1843, March 2011. (PMID: 21239552) (Impactor factor: 3.778)
17. Hu, J., Schilder, M.* and Yan, X. A Neighor-Weighted K-Nearest Neighbor Method For Predicting Protein Subnuclear Localizations (poster paper). IEEE 1st International Conference on Computational Advances in Bio and Medical Sciences (ICCABS'11), pp. 247, Feb 3-. 2011, Orlando, FL, USA. (ISBN: 978-1-61284-851-8 ) (doi 10.1109/ICCABS.2011.5729900 ) (Acceptance rate: 42%)
2010
16. Hu, J. and Yan, C. A comparative Analysis of Protein Interfaces. Protein Pept. Lett., vol 17, issue 11, 1450-1458, 2010. (Impact factor: 1.755)
15. Hu, J. Predicting Subcellular Localization of Gram-negative Proteins with Improved Performance. In proceeding of 2nd International Conference on Bioinformatics and Computational Biology (BICoB), Honolulu, Hawaii, USA, March 24-26, 2010. (Acceptance rate: 45%)
2009
14. Hu, J. and Yan, C. A tool for calculating binding-site residues on proteins from PDB structures. BMC Structural Biology, 2009, 9:52.3. (Impact factor: 2.79)
2008
13. Hu, J. and Yan, C. A Method for Discovering Transmembrane Beta-barrel Proteins in Gram-negative Bacterial Proteomes.Computational Biology and Chemistry, 2008 32:298-301. (Impact factor: 1.37)
12. Hu, J. and Yan, C. Identification of Deleterious Non-synonymous Single Nucleotide Polymorphisms Using Only Sequence-derived Information, BMC Bioinformatics, 2008, 9:297. (Impact factor: 3.43)
11. Hu, J. and Yan, C. Protein Subcellular Localisation Prediction with Improved Performance. International Journal of Functional Informatics and Personalised Medicine. 2008, 1 (3), 321-328.
10. Hu, J., and Yan, C. HMM_RA: An Improved Method for Alpha-helical Transmembrane Protein Topology Prediction. Bioinformatics and Biology Insights, 2008 2: 67-74.
9. Yan, C., Hu, J., and Wang, Y. Discrimination of Outer Membrane Proteins Using a K-nearest Neighbor Method. Amino Acids,2008 35(1):65-73. (Impact factor: 3.88)
8. Yan, C., Hu, J., and Wang, Y. Discrimination of Outer Membrane Proteins with Improved Performance. BMC Bioinformatics,2008, 9:47. (Impact factor: 3.43)
7. Hu, J. and Yan, C. Mining Sequence Features for DNA-binding Site Prediction. In Proceedings of IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 2008.
2007
6. Hu, J. and Yan, C. Predicting Protein Subcellular Localizations Using Weighted Euclidian Distance. In Proceedings of IEEE 7th International Symposium on BioInformatics and BioEngineering, 2007, 1370-1373.
2006
5. Yan, C. and Hu, J. An Exploration to the Combining of Solvent Accessibility With Amino Acid Sequence in the Identification of Helix-Turn-Helix motifs, WSEAS Transaction on Biology and Biomedicine, 2006,6(3): 477-484.
4. Yan, C. and Hu, J. Identification of Helix-Turn-Helix Motifs From Amino Acid Sequence. In Proceedings of IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology, 2006, 1-7.
3. Yan, C. and Hu, J. A Hidden Markov Model for the Identification of Helix-Turn-Helix Motifs. In Proceedings of WSEAS International Conference on Cellular and Molecular Biology-Biophysics and Bioengineering, 2006, 14-19.
2. de Garis, H., Liu, R., Huang, D. and Hu, J. Artificial Brains. An Inexpensive Method for Accelerating the Evolution of Neural Network Modules for Building Artificial Brains, In Proceedings of the AGI Workshop, 2006, 144-158.
2005
1. Flann N. S., Hu J., Bansal M., Patel V. and Podgorski G. Biological Development of Cell Patterns: Characterizing the Space of Cell Chemistry Genetic Regulatory Networks. In Proceedings of Eighth European Conference on Artificial Life, 2005, 57-66.
Presentations
1. Poster presentation, "Predicting the effects of 3n indels", The Pacific Symposium on Biocomputing (PSB) 2013.
2. Invited Talk: "Predicting the effects of frameshifting indels using a machine learning approach", Dickinson College, 2012.
3. Poster presentation, "SIFT Indel: an on-line tool for predicting the effects of frame shifting indels", 2012 Pacific Symposium on Biocomputing (PSB 2012)
4. Poster presentation, "BS-KNN: A K-Nearest Neighbor Method for Predicting Protein Subchloroplast Locations Based on Bit-Score Weighted Euclidian Distance", ACM-BCB 2011
5. Oral Presentation: "Identification of Transmembrane β-Barrel Proteins Using a K-Nearest Neighbor Method Based On Weighted Manhattan Distance", 2010 International Conference on Bioinformatics & Computational Biology (BIOCOMP' 10), Las Vegas, NV, July 12-15, 2010.
6. Oral Presentation: "Predicting Subcellular Localization of Gram-negative Proteins with Improved Performance", 2nd International Conference on Bioinformatics and Computational Biology (BICoB), Honolulu, Hawaii, USA, March 24-26, 2010.
7. Poster Presentation: "A Useful Tool for Calculating Binding-site Residues on Proteins from PDB Structures", 7th Annual Rocky Mountain Bioinformatics Conference, Aspen, CO, December 10-12, 2009.
Grants and Awards
Computational Drug Repositioning (Second Amendment), Industry grant offered by GlaxoSmithKline LLC, $39,972, 7/1/2014 - 6/30/2015, Principal Investigator.
Computational Drug Repositioning (First Amendment), Industry grant offered by GlaxoSmithKline LLC, $38,609, 8/1/2013 - 6/30/2014, Principal Investigator.
Computational Drug Repositioning, Industry grant offered by GlaxoSmithKline LLC, $99,723, 8/1/2012 - 7/31/2013, Principal Investigator.